Description
An inhibitor of influenza neuraminidase; inhibits neuraminidase activity in clinical isolates of influenza A subtypes H1N1 and H3N2 and influenza B (geometric mean IC50s = 0.73, 1.64, and 11.21 nM, respectively); inhibits replication of influenza A and B in isolated human respiratory epithelial cells (EC90s = <0.01 mg/L and 0.25-0.54 mg/L, respectively); reduces lung viral titers in mice infected with influenza A or B at 0.4 mg/kg intranasally